| Overview |
| bs-15436R-A750 |
| HEAB Polyclonal Antibody, ALEXA FLUOR® 750 Conjugated |
| WB, IF(IHC-P), IF(IHC-F), IF(ICC) |
| Human, Mouse, Rat, Cow, Horse, Rabbit |
| Specifications |
| ALEXA FLUOR® 750 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human HEAB |
| 1-100/425 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 10978 |
| Nucleus |
| ATP/GTP binding protein; CLP 1; clp1; CLP1 cleavage and polyadenylation factor I subunit homolog; CLP1, cleavage and polyadenylation factor I subunit, homolog S. cerevisiae; CLP1, yeast, homolog of; CLP1_HUMAN; hClp1; Homolog of yeast CFIA subunit Clp1p; Polynucleotide kinase Clp1; Pre mRNA cleavage complex II protein Clp1; Pre-mRNA cleavage complex II protein Clp1. |
| HEAB is a 425 amino acid nuclear protein that belongs to the Clp1 family. Utilizing magnesium, manganese or nickel as cofactors, HEAB participates in the phosphorylation of the 5'-hydroxyl groups of double- and single- stranded RNA and DNA. HEAB is a member of the tRNA splicing endonuclease complex, in conjunction with TSEN2, TSEN15, TSEN34 and TSEN54, and is also a member of the pre-mRNA cleavage complex II. The gene encoding HEAB maps to human chromosome 11q12.1 and mouse chromosome 2 D; mutations to this gene may lead to a reduced pre-mRNA cleavage activity. HEAB exists as two isoforms due to alternative splicing events. |
| Application Dilution |
| WB |
1:300-5000 |
| IF(IHC-P) |
1:50-200 |
| IF(IHC-F) |
1:50-200 |
| IF(ICC) |
1:50-200 |
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