Overview |
bs-16929R-HRP |
KCTD17 Polyclonal Antibody, HRP Conjugated |
ELISA, IHC-P, IHC-F |
Mouse, Rat |
Human, Cow, Pig |
Specifications |
HRP |
Rabbit |
KLH conjugated synthetic peptide derived from human KCTD17 |
1-100/521 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target |
79734 |
Q8N5Z5 |
Cytoplasm |
BTB; BTB/POZ domain-containing protein KCTD17; FLJ12242; FLJ98761; KCD17_HUMAN; KCTD17; Potassium channel tetramerisation domain containing 17; POZ domain-containing protein KCTD17; RP5-1170K4.4. |
Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598). May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243). |
Application Dilution |
ELISA |
1:500-1000 |
IHC-P |
1:200-400 |
IHC-F |
1:100-500 |