Angiotensin 1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated

Applications

WB
IF(IHC-P)
IF(IHC-F)
IF(ICC)

Reactivity

Mouse

Predicted Reactivity

Human
Rat
Dog
Sheep
Horse

Overview
Catalog #	bs-1707R-A647
Product Name	Angiotensin 1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated
Applications	WB, IF(IHC-P), IF(IHC-F), IF(ICC)
Specificity	Immunogen used for this antibody is DRVYIHPFHL, corresponding to amino acids 34-43 of human Angiotensinogen.
Reactivity	Mouse
Predicted Reactivity	Human, Rat, Dog, Sheep, Horse
Specifications
Conjugation	ALEXA FLUOR® 647
Host	Rabbit
Source	KLH conjugated synthetic peptide of human Angiotensin I
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition	Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID	183
Subcellular location	Secreted
Synonyms	AGT; Alpha 1 antiproteinase antitrypsin; Ang I; Ang II; Ang III; Angiotensin 1; Angiotensin; Angiotensin I; Angiotensin II; Angiotensin-2; Angiotensin III; Angiotensin-3; Angiotensinogen; Angiotensinogen serpin peptidase inhibitor clade A member 8; ANGT_HUMAN; Angiotensin 1-10; Angiotensin 1-8; ANHU; Des-Asp[1]-angiotensin II; FLJ92595; FLJ97926; OTTHUMP00000035878; Pre angiotensinogen; Serine or cysteine proteinase inhibitor; Serpin A8; Serpin peptidase inhibitor, clade A, member 8; SERPINA8.
Background	Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3: stimulates aldosterone release. Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
Application Dilution
WB	1:300-5000
IF(IHC-P)	1:50-200
IF(IHC-F)	1:50-200
IF(ICC)	1:50-200

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