| Overview |
| bs-18144R-Biotin |
| IL1RAP Polyclonal Antibody, Biotin Conjugated |
| ELISA, IHC-P |
| Mouse |
| Human, Rat |
| Specifications |
| Biotin |
| Rabbit |
| KLH conjugated synthetic peptide derived from human IL1RAP/IL1R3 |
| 251-350/570 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 3556 |
| Q9NPH3 |
| Secreted, Cell membrane |
| IL1R3; C3orf13; IL-1RAcP; Interleukin-1 receptor accessory protein; IL-1 receptor accessory protein; Interleukin-1 receptor 3; IL-1R-3; IL-1R3; IL1RAP |
| Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. |
| Application Dilution |
| ELISA |
1:500-1000 |
| IHC-P |
1:200-400 |
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