nNOS Ser1417 Polyclonal Antibody, AbBy Fluor® 647 Conjugated

Overview
Catalog #	bs-19301R-BF647
Product Name	nNOS Ser1417 Polyclonal Antibody, AbBy Fluor® 647 Conjugated
Applications	WB, IF(IHC-P), IF(IHC-F), IF(ICC)
Reactivity	Human, Rat, Xenopus laevis
Predicted Reactivity	Mouse, Zebrafish
Specifications
Conjugation	AbBy Fluor® 647
Host	Rabbit
Source	KLH conjugated Synthesised phosphopeptide derived from human nNOS around the phosphorylation site of Ser1417
Modification Site	Ser1417
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition	Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID	842
Swiss Prot	P55211
Subcellular location	Cell membrane
Synonyms	MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; ICE-like apoptotic protease 6; CASP9
Background	Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Application Dilution
WB	1:300-5000
IF(IHC-P)	1:50-200
IF(IHC-F)	1:50-200
IF(ICC)	1:50-200

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