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CD33 Polyclonal Antibody, PE Conjugated

Applications

  • WB

Reactivity

  • Mouse
Overview
Catalog # bs-23755R-PE
Product Name CD33 Polyclonal Antibody, PE Conjugated
Applications WB
Reactivity Mouse
Specifications
Conjugation PE
Host Rabbit
Source KLH conjugated synthetic peptide derived from mouse CD33
Immunogen Range 101-200/403
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 12489
Swiss Prot Q63994
Subcellular location Cell membrane
Synonyms CD33_HUMAN; CD33 antigen; CD33 molecule; FLJ00391; gp67; Myeloid cell surface antigen CD33; Myeloid cell surface antigen CD33 precursor; p67; Sialic acid binding Ig like lectin 3; Sialic acid binding immunoglobulin like lectin 3; SIGLEC3; Siglec-3.
Background Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
Application Dilution
WB 1:300-5000