AQP7 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated

Applications

FCM
IF(IHC-P)
IF(IHC-F)
IF(ICC)

Reactivity

Human
Mouse
Rat
Others

Predicted Reactivity

Dog
Cow
Pig
Chicken

Overview
Catalog #	bs-2506R-A488
Product Name	AQP7 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated
Applications	FCM, IF(IHC-P), IF(IHC-F), IF(ICC)
Reactivity	Human, Mouse, Rat, Others
Predicted Reactivity	Dog, Cow, Pig, Chicken
Specifications
Conjugation	ALEXA FLUOR® 488
Host	Rabbit
Source	KLH conjugated synthetic peptide derived from human AQP7
Immunogen Range	251-342/342
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition	Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID	364
Swiss Prot	O14520
Subcellular location	Cell membrane
Synonyms	AQP9; AQP7L; AQPap; GLYCQTL; Aquaporin-7; AQP-7; Aquaglyceroporin-7; Aquaporin adipose; Aquaporin-7-like; AQP7
Background	Water is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein "aquaporin". Over the last decade, genes for several members of aquaporin family have been cloned, expressed, and their distribution studied in many tissues. AQP0 or MIP26 (major intrinsic protein 26kD), and Aquaporin 1 (AQP1, purified from red cells) also called CHIP28 (channel forming integral protein, 28kD; 268aa; gene locus 7p14) has been the foundation of the growing family of aquaporin. The lens specific AQP0 represents up to 80% of total lens membrane protein. Defects in MIP26 are cause of autosomal dominant cataract. The cataract Fraser mutation (CATFR or Shriveled) is a transposon induced splicing error that substitutes a long terminal repeat sequence for the C terminus of MIP. The lens opacity mutation (LOP) is an amino acid substitution that inhibits targeting of MIP to the cell membrane.
Application Dilution
FCM	1:20-100
IF(IHC-P)	1:50-200
IF(IHC-F)	1:50-200
IF(ICC)	1:50-200

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