ALK (Tyr1604) Polyclonal Antibody, APC Conjugated

Applications

FCM
IF(IHC-P)
IF(IHC-F)
IF(ICC)

Reactivity

Human
Others

Predicted Reactivity

Pig
Guinea Pig

Overview
Catalog #	bs-3022R-APC
Product Name	ALK (Tyr1604) Polyclonal Antibody, APC Conjugated
Applications	FCM, IF(IHC-P), IF(IHC-F), IF(ICC)
Reactivity	Human, Others
Predicted Reactivity	Pig, Guinea Pig
Specifications
Conjugation	APC
Host	Rabbit
Source	KLH conjugated synthetic phosphopeptide derived from human ALK around the phosphorylation site of Tyr1604
Modification Site	Tyr1604
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition	Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID	238
Swiss Prot	Q9UM73
Subcellular location	Cell membrane
Synonyms	ALK Tyr1604; ALKY1604; p-ALKTyr1604; p-ALKY1604; ALK tyrosine kinase receptor precursor; ALK/EML4 fusion gene, included; ALK/NPM1 fusion gene, included; anaplastic lymphoma kinase Ki-1; Anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki 1; Anaplastic lymphoma kinase Ki1; Anaplastic lymphoma kinase p80 CD 246; CD246; CD246 antigen; EC 2.7.10.1 Ki 1; Ki1; NBLST3; Tcrz; TFG/ALK; ALK_HUMAN.
Background	This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), LK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011].
Application Dilution
FCM	1:20-100
IF(IHC-P)	1:50-200
IF(IHC-F)	1:50-200
IF(ICC)	1:50-200

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