| Overview |
| bs-3516R-A594 |
| WBSCR14 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated |
| IF(IHC-P), IF(IHC-F), IF(ICC) |
| Rat |
| Human, Mouse, Dog, Cow, Pig, Horse, Chicken |
| Specifications |
| ALEXA FLUOR® 594 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human WBSCR14/ChREBP |
| 81-180/852 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 51085 |
| Nucleus |
| ChREBP; bHLHd14; Carbohydrate responsive element binding protein; MIO; MLX interacting protein like; Mlx interactor; MLXIPL; MONDOB; WBSCR 14; WBSCR14; Williams Beuren syndrome chromosome region 14; Williams Beuren syndrome chromosome region 14 protein; WS basic helix loop helix leucine zipper protein; WS bHLH; MLXPL_HUMAN. |
| ChREBP (Carbohydrate responsive element binding protein) is a transcription factor playing a critical role in the nutrient and hormonal regulation of genes encoding enzymes of glucose metabolism and lipogenesis pathways. It contains several domains including a nuclear localization signal (NLS) near the N-terminus, polyproline domains, a basic helix-loop-helix leucine zipper (b/HLH/Zip) and a leucine zipper like (zip-like) domain.ChREBP is ubiquitously detected in various tissues, with highest expression in liver, kidney and white and brown adipose tissue. Under basal conditions ChREBP is localized in the cytosol, translocating into the nucleus upon high glucose stimulation following its dephosphorylation of serine 196. |
| Application Dilution |
| IF(IHC-P) |
1:50-200 |
| IF(IHC-F) |
1:50-200 |
| IF(ICC) |
1:50-200 |
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