| Overview |
| bs-5081R-A750 |
| Lamin B Receptor Polyclonal Antibody, ALEXA FLUOR® 750 Conjugated |
| WB, FCM |
| The immunogen for this product has partial sequence similarity to SEPT8 and SEPT2 |
| Human, Mouse |
| Rat, Cow, Horse, Rabbit |
| Specifications |
| ALEXA FLUOR® 750 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human Lamin B Receptor |
| 1-100/615 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 3930 |
| Q14739 |
| Cytoplasm, Nucleus, Cell membrane |
| PHA; LMN2R; TDRD18; DHCR14B; Lamin-B receptor; Integral nuclear envelope inner membrane protein; LBR |
| Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization. Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. The cleavage of lamins results in nuclear disregulation and cell death. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
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