| Overview |
| bs-8442R-PerCP-Cy7 |
| C-Myc(Ser373) Polyclonal Antibody, PerCP-Cy7 Conjugated |
| WB, FCM |
| Human, Mouse |
| Rat, Cow, Pig |
| Specifications |
| PerCP-Cy7 |
| Rabbit |
| KLH conjugated synthetic phosphopeptide derived from human C-Myc around the phosphorylation site of Ser373 |
| Thr373 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 4609 |
| Nucleus |
| MycSer373; MycS373; p-MycSer373; p-MycS373; AU016757; Avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; Cellular myelocytomatosis oncogene; |
| The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
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