| Overview |
| bs-8571R-A555 |
| Histone H2A.X (Ubiquityl Lys119) Antibody, ALEXA FLUOR® 555 Conjugated |
| WB, IF(IHC-P), IF(IHC-F), IF(ICC) |
| This modification site is homologous to that of Lys119 in Rat. |
| Human, Mouse, Rat |
| Cow, Pig, Rabbit |
| Specifications |
| ALEXA FLUOR® 555 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human Ubiquityl Histone H2A.X (Lys119) |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 3014 |
| P16104 |
| Nucleus |
| H2AX; H2A.X; H2A/X; Histone H2AX; Histone H2A.X; H2AFX |
| Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. |
| Application Dilution |
| WB |
1:300-5000 |
| IF(IHC-P) |
1:50-200 |
| IF(IHC-F) |
1:50-200 |
| IF(ICC) |
1:50-200 |
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