| Overview |
| bsm-54042R |
| Bag3 (8D8) Monoclonal Antibody |
| WB, IHC-P |
| Human |
| Specifications |
| Unconjugated |
| Rabbit |
| N terminal human Bag3 |
| Monoclonal |
| 8D8 |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
| Store for 1 year at -20C from date of shipment. Store for 1 year at -20C from date of shipment. |
| Target |
| 9531 |
| O95817 |
| BAG family molecular chaperone regulator 3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1, BAG-3, BAG3, BIS |
| The Bag family of proteins are characterized by the presence of a 45 amino acid Bag domain through which they bind with high affinity to the ATPase domain of HSP 70, thereby negatively regulating HSP 70 chaperone activity. Bag-3 (Bcl-2-associated athanogene 3), also known as BIS or CAIR-1, is a 575 amino acid protein that contains one C-terminal Bag domain and two N-terminal WW domains. Like other members of the Bag family, Bag-3 functions to inhibit the chaperone activity of HSP 70, specifically by promoting the release of HSP 70-bound substrates. Additionally, Bag-3 exhibits anti-apoptotic activity via cell cycle control, suggesting a possible role for Bag-3 in tumor progression. The gene encoding Bag-3 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. |
| Application Dilution |
| WB |
1:300-5000 |
| IHC-P |
1:200-400 |
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