| Overview |
| bsm-54055R |
| 5HT2C Receptor (4C3) Monoclonal Antibody |
| WB, IHC-P |
| Human, Mouse, Rat |
| Specifications |
| Unconjugated |
| Rabbit |
| C-terminal human 5HT2C Receptor |
| Monoclonal |
| 4C3 |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
| Store at 4C for up to 2 weeks. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Target |
| 3358 |
| P28335 |
| 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1C, Serotonin receptor 2C, 5-HT-2C, 5-HT2C, 5-HTR2C, 5-HT-1C, 5-HT1C, HTR2C, HTR1C |
| G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis. |
| Application Dilution |
| WB |
1:300-5000 |
| IHC-P |
1:200-400 |
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