| Overview |
| bsm-54313R |
| Frizzled 8 (3G4) Monoclonal Antibody |
| WB, IHC-P |
| Human, Mouse |
| Specifications |
| Unconjugated |
| Rabbit |
| Synthetic peptide within human Frizzled 8 aa 600-690 |
| Monoclonal |
| 3G4 |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
| Store at 4C for up to 2 weeks. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Target |
| Q9H461 |
| Golgi apparatus |
| Frizzled-8; Fz-8; hFz8; FZD8 |
| Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. |
| Application Dilution |
| WB |
1:300-5000 |
| IHC-P |
1:200-400 |
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