| Overview |
| bsm-54391R |
| EGR2 (5C5) Monoclonal Antibody |
| WB, FCM |
| Human, Mouse, Rat |
| Specifications |
| Unconjugated |
| Rabbit |
| Recombinant protein within human EGR2 aa 1-200. |
| Monoclonal |
| 5C5 |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
| Store at 4C for up to 2 weeks. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Target |
| P11161 |
| Nucleus |
| E3 SUMO-protein ligase EGR2; AT591; E3 SUMO-protein transferase ERG2; Early growth response protein 2; Zinc finger protein Krox-20; EGR-2; EGR2; KROX20 |
| The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Binds to two specific DNA sites located in the promoter region of HOXA4. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
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