Recombinant human ST2 protein, N-His

Overview
Catalog #	bs-41103p-100ug
Product Name	Recombinant human ST2 protein, N-His
Applications	ELISA
Reactivity	Others
Specifications
Conjugation	Unconjugated
Source	Recombinant human ST2 protein, N-His protein is expressed in E.coli with N-His. It contains the amino acid sequence of 19-328/556.
Storage Buffer	20mM Tris-HCl (pH7.2) with 1M Urea.
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	9173
Swiss Prot	Q01638
Background	ST2 is a member of a superfamily containing the Interleukin 1 (IL1) receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. ST2 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF. More recently, it has been shown to negatively regulate IL1 receptor and Toll-like receptor 4 (TLR4) signaling and to maintain endotoxin tolerance. It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP.