Recombinant human ADAMTS13 protein,N-His

$\tThe purity of the protein is greater than 90% as determined by reducing SDS-PAGE.$

Overview
Catalog #	bs-42478p-100ug
Product Name	Recombinant human ADAMTS13 protein,N-His
Applications	Others
Reactivity	Others
Specifications
Conjugation	Unconjugated
Source	Recombinant human ADAMTS13 protein in E.coli with N-His. It contains the amino acid sequence of 75-441/1427
Storage Buffer	0.01M TBS(pH7.4)
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	11093
Swiss Prot	Q76LX8
Background	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2008].