FADD Polyclonal Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bs-55075R |
| Product Name | FADD Polyclonal Antibody |
| Applications | WB, IP, IHC |
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | Recombinant fusion protein containing a sequence corresponding to amino acids 1-208 of human FADD (NP_003815.1). |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C for 12 months. |
| Target | |
| Gene ID | 8772 |
| Swiss Prot | Q13158 |
| Subcellular location | Cytoplasm, Cell membrane |
| Synonyms | GIG3;MORT1;FADD;FADD |
| Background | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. |
| Application Dilution | |
| WB | 1:300-5000 |
| IP | 1-2ug |
| IHC | |
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