BMP1 Polyclonal Antibody, APC-Cy7 Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bs-6401R-APC-Cy7-100uL |
| Product Name | BMP1 Polyclonal Antibody, APC-Cy7 Conjugated |
| Applications |
WB
|
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | APC-Cy7 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human BMP1 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 649 |
| Synonyms | BMP 1; BMP-1; Bone morphogenetic protein 1; Mammalian tolloid protein; mTld; PCOLC; PCP; ProCollagen C endopeptidase; Procollagen C proteinase; TLD; BMP1_HUMAN. |
| Background | Bone morphogenetic protein 1 (BMP1) was first identified in osteogenic extracts of bone. It is an extracellular zinc endopeptidase, implicated in morphogenetic processes in a broad range of species. BMP1 is a member of the astacin family of metalloproteinases. The astacin family includes BMP1, astacin, meprin A and B, tolloid-like proteins, and choriolysin. BMP1 is involved in extracellular matrix (ECM) formation, suggesting that a functional link may exist between astacin metalloproteinases, growth factors, and cell differentiation and pattern formation during development. The name PCP reflects this enzyme۪s involvement in the collagen deposition of growing bone. The enzymes known as the procollagen C and N proteinases (PCP and PNP) are involved in the processing of fibrillar procollagen precursors to mature collagens, which is an essential requirement for fibril formation. PCP cleaves the C-terminus from procollagen, to allow the formation of mature, triplehelical collagen. The N-terminus is cleaved by the procollagen N-proteinase (PNP or ADAM-TS2). Defects in PNP have been linked to the skin disorder dermatosparaxis, and defects in BMP1 are thought to lead to aberrant collagen processing, and connective tissue disorders. Many forms of BMP1 have been reported, with varying truncation at the C-terminus. The long form of BMP1 is most similar to the tolloid-like proteins, which have extra EGF-like and CUB domains. |
| Application Dilution | |
| WB | 1:500-2000 |
Frequently asked questions
Which applications is BMP1 Polyclonal Antibody, APC-Cy7 Conjugated (bs-6401R-APC-Cy7) validated for, and at what dilution?
bs-6401R-APC-Cy7 is validated for WB (1:500-2000). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does BMP1 Polyclonal Antibody, APC-Cy7 Conjugated (bs-6401R-APC-Cy7) react with?
Tested reactivity: Human, Mouse, Rat.
How should bs-6401R-APC-Cy7 be stored?
Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise BMP1 Polyclonal Antibody, APC-Cy7 Conjugated (bs-6401R-APC-Cy7)?
KLH conjugated synthetic peptide derived from human BMP1
What are the excitation and emission wavelengths of the APC-Cy7 conjugate (bs-6401R-APC-Cy7)?
APC-Cy7 on bs-6401R-APC-Cy7: excitation / emission 650nmn/780nm.