6-Carboxy-2',7'-dichlorofluorescein DA
| Overview | |
| Catalog # | bs-76072c-100mg |
| Product Name | 6-Carboxy-2',7'-dichlorofluorescein DA |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 144489-10-1 Molecular formula: C25H14CI2O9 Molecular weight: 529.29 Purity: >97% (NMR) Appearance: White to off-white powder. Solubility: Soluble in DMSO or chloroform. Insoluble in water. InChiKey: FCNONRRKVDBQRD-UHFFFAOYSA-N SMILES: O=C(O1)C2=C(C=C(C(O)=O)C=C2)C31C4=C(C=C(OC(C)=O)C(Cl)=C4)OC5=CC(OC(C)=O)=C(Cl)C=C53 |
| Description | Fluorescent indicator. The non-fluorescent 6-CDCF DA passively diffuses across the cell membrane and is hydrolyzed to fluorescent CDCF by intracellular esterases. It has been shown to be highly sensitive, long-lasting, cell-permeant and fluorescein-based tracer for quantifying ROS generation. Substrate for MRP2 and MRP3 and therefore the function of the efflux transporters (hepatic exrection) and multi-drug resistance associated proteins MRP2 and MRP3 can be measured using 6-CDCF DA. The CDCFDA/CDCF technoique provides a fast screening tool for MRP2 substrates and/or inhibitors. Spectral data: lambdaEx=502nm; lambdaEm=530nm. |
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