5-Fluorocytosine
| Overview | |
| Catalog # | bs-76318c-1g |
| Product Name | 5-Fluorocytosine |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 2022-85-7 Molecular formula: C4H4FN3O Molecular weight: 129.09 Purity: >99% (TLC) Appearance: White to off-white powder. Solubility: Soluble in water. InChiKey: XRECTZIEBJDKEO-UHFFFAOYSA-N SMILES: NC1=NC(=O)NC=C1F SMILES: NC1=NC(=O)NC=C1F |
| Description | Fluorinated pyrimidine analog. Antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil (a widely used cytotoxic drug) and further metabolized to fluorinated ribo- and deoxyribonucleotides. Inhibits DNA and RNA synthesis and interfers with ribosomal protein synthesis. Displays antifungal and antitumor activity. Lately with the development of gene therapy, it has been introduced as a prodrug in combination with the cytosine deaminase suicide gene as antitumor compound, significantly improving survival and reducing tumor size in selected tumors. |
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