5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione
| Overview | |
| Catalog # | bs-76687c-5mg |
| Product Name | 5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 587852-28-6 Molecular formula: C13H13NO3S Molecular weight: 263.3 Purity: >95% (HPLC) Appearance: Yellow powder. Solubility: Soluble in DMSO. InChiKey: GBWOSXZUTXXXQF-FLIBITNWSA-N SMILES: CCCOC1=CC=C(\C=C2/SC(=O)NC2=O)C=C1 |
| Description | Potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1alpha (68% inhibition of DYRK1alpha and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (<18% inhibition at 5 µM). Reported to exhibit antitumor activity in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20| 50 mg/kg via daily i.p.). |
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