AK-7

Overview
Catalog #	bs-83208c-25mg
Product Name	AK-7
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	A selective Sirt2 inhibitor (IC50=15.5 µM) which does not inhibit Sirt1 or Sirt31. It down regulates cholesterol biosynthesis genes in primary striatal neurons1. Displays neuroprotective effects in Huntington’s disease mouse models including improved motor function, extended survival and reduced brain atrophy all of which were associated with reduced aggregated mutant huntingtin2.
Description	CAS Number: 420831-40-9 Chemical Name: SIRT2 inhibitor Molecular Weight: 437.36 Formula: C19H21BrN2O3S Solubility: DMSO (50 mg/ml) Ethanol (8 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)