Ube2N Polyclonal Antibody, HRP Conjugated

Applications

ELISA
IHC-P
IHC-F

Reactivity

Mouse
Rat
Others

Predicted Reactivity

Human
Dog
Cow
Horse
Chicken
Rabbit

Overview
Catalog #	bs-8351R-HRP
Product Name	Ube2N Polyclonal Antibody, HRP Conjugated
Applications	ELISA, IHC-P, IHC-F
Reactivity	Mouse, Rat, Others
Predicted Reactivity	Human, Dog, Cow, Horse, Chicken, Rabbit
Specifications
Conjugation	HRP
Host	Rabbit
Source	KLH conjugated synthetic peptide derived from human Ube2N/UBC13
Immunogen Range	56-152/152
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition	Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID	7334
Subcellular location	Cytoplasm, Nucleus
Synonyms	UBC 13; UBC13; UbCH ben; Ube 2N; Ube2n; UBE2N_HUMAN; ubiquitin carrier protein N; Ubiquitin conjugating enzyme E2 N; Ubiquitin conjugating enzyme E2N homologous to yeast UBC13; Ubiquitin conjugating enzyme E2N UBC13 homolog yeast; Ubiquitin conjugating enzyme E2N; ubiquitin protein ligase N; Ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N homologous to yeast UBC13; ubiquitin-conjugating enzyme E2N UBC13 homolog yeast; Ubiquitin-protein ligase N; Yeast UBC13 homolog; bendless like ubiquitin conjugating enzyme; Bendless-like ubiquitin-conjugating enzyme; BLU; EC 6.3.2.19; Human epidermoid carcinoma mRNA for ubiquitin-conjugating enzyme E2 similar to Drosophila bendless gene product complete cds; MGC131857; MGC8489.
Background	Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). UBC13, also known as UBE2N or BLU, is a 152 amino acid member of the E2 ubiquitin-conjugating enzyme family. Existing as a heterodimer with Mms2 (also known as UBE2V2), UBC13 catalyzes the ATP-dependent synthesis of non-canonical polyubiquitin chains, a process that does not lead to proteasomal degradation. Additionally, UBC13 mediates the transcription of several target genes and is thought to play a role in cell cycle progression, cellular differentiation and DNA repair mechanisms that ensure cell survival after DNA damage.
Application Dilution
ELISA	1:500-1000
IHC-P	1:200-400
IHC-F	1:100-500

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