Cortactin (1T3) Monoclonal Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bsm-51120M-100uL |
| Product Name | Cortactin (1T3) Monoclonal Antibody |
| Applications |
WB
|
| Reactivity | Human |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Mouse |
| Source | Purified His-tagged Cortactin protein(Fragment) was used to produced this monoclonal antibody. |
| Clonality | Monoclonal |
| Clone # | 1T3 |
| Isotype | IgM |
| Concentration | Lot Dependent |
| Purification | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C for 12 months. |
| Target | |
| Gene ID | 2017 |
| Swiss Prot | Q14247 |
| Synonyms | EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1; CTTN |
| Background | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). |
| Application Dilution | |
| WB | 1:300-5000 |
Frequently asked questions
Which applications is Cortactin (1T3) Monoclonal Antibody (bsm-51120M) validated for, and at what dilution?
bsm-51120M is validated for WB (1:300-5000). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does Cortactin (1T3) Monoclonal Antibody (bsm-51120M) react with?
Tested reactivity: Human.
How should bsm-51120M be stored?
Store at -20°C for 12 months. Storage buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise Cortactin (1T3) Monoclonal Antibody (bsm-51120M)?
Purified His-tagged Cortactin protein(Fragment) was used to produced this monoclonal antibody.