IL-1R1 (Tyr496) Blocking Peptide
| OVERVIEW | |
| CATALOG # | bs-5394P |
| PRODUCT NAME |
IL-1R1 (Tyr496) Blocking Peptide
|
| CONJUGATION | Unconjugated |
| SOURCE | Synthetic phosphopeptide derived from human IL-1R1 around the phosphorylation site of Tyr496, and falls within the range 480-510/569 amino acids. |
| PURIFICATION: | Purified by HPLC/MS. |
| STORAGE |
The product should be stored at -70℃ or -20℃. |
| TARGET | |
|
ACCESSION |
3554 |
| UNIPROT |
P14778 |
| BACKGROUND |
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. |
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