| Overview |
| bs-0876r-pe-cy7-100ul |
| phospho-AKT (Ser473) Polyclonal Antibody, PE-Cy7 Conjugated |
| WB |
| Human, Mouse, Rat |
| Specifications |
| PE-Cy7 |
| Rabbit |
| KLH conjugated synthetic phosphopeptide derived from human AKT1 around the phosphorylation site of Ser473 |
| Ser473 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 24185 |
| P47196 |
| Cytoplasm, Nucleus, Cell membrane |
| Akt; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; RAC-PK-alpha; Akt1 |
| AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation. |
| Application Dilution |
| WB |
1:500-2000 |
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