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Acetyl Coenzyme A Carboxylase beta (Ser220) Antibody, Biotin Conjugated

Applications

  • ELISA
  • IHC-P
  • IHC-F

Predicted Reactivity

  • Human
Overview
Catalog # bs-12952R-Biotin
Product Name Acetyl Coenzyme A Carboxylase beta (Ser220) Antibody, Biotin Conjugated
Applications ELISA, IHC-P, IHC-F
Predicted Reactivity Human
Specifications
Conjugation Biotin
Host Rabbit
Source KLH conjugated synthetic phosphopeptide derived from human Acetyl Coenzyme A Carboxylase beta around the phosphorylation site of Ser220
Modification Site Ser220
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Swiss Prot O00763
Subcellular location Cell membrane
Synonyms Acetyl Coenzyme A Carboxylase beta phospho S220; Acetyl Coenzyme A Carboxylase beta phospho Ser2210 p-Acetyl Coenzyme A Carboxylase beta phospho S220; ACACB_HUMAN
Background Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Application Dilution
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500