ACCN1 Polyclonal Antibody, HRP Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bs-4915r-hrp-100uL |
| Product Name | ACCN1 Polyclonal Antibody, HRP Conjugated |
| Applications |
IHC-P
|
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | HRP |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human CD8B |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 40 |
| Subcellular location | Extracellular |
| Synonyms | ACCN; ASIC2a; BNaC1; ASIC2; ASICs2ACCN1_HUMAN;Acid sensing ion channel 2;Acid-sensing ion channel 2;Amiloride sensitive brain sodium channel;Amiloride sensitive cation channel 1 neuronal degenerin;Amiloride sensitive cation channel 1 neuronal;Amiloride-sensitive brain sodium channel;Amiloride-sensitive cation channel 1, neuronal;Amiloride-sensitive cation channel neuronal 1;ASIC2;ASIC2a;BNaC1;BNC1;Brain sodium channel 1;Degenerin;hBNaC1;Mammalian degenerin homolog;MDEG;Neuronal amiloride sensitive cation channel 1. |
| Background | Degenerin/epithelial sodium channel (DEG/ENaC) superfamily members are amiloride-sensitive sodium channels that contain intracellular N- and C-termini, 2 two hydrophobic transmembrane regions and a cysteine-containing extracellular loop. Acid sensing ion channel ASIC1, also designated ACCN2, BNAC2 and ASIC1a, is present in brain as a 4.3-kb transcript with localization to rat dorsal root ganglia. In situ hybridization of rat brain suggests that ASIC1 is most abundant in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei and cerebellum. ASIC1 and H+-gated currents may contribute to the development of fear and anxiety. ASIC2, also designated amiloride-sensitive cation channel 1, neuronal (ACCN1), mammalian degenerin, BNAC1 (MDEG) and brain Na+ channel 1, mediates the normal detection of light touch. ASIC2 mRNA is abundant in brain, specifically in neurons. ASIC2 is expressed as 2.7- and 3.7-kb transcripts in brain and spinal cord tissues. ASIC3, also designated ASIC3, SLNAC1 and TNaC1, mediates detection of lasting pH changes and is involved in modulating moderate- to high-intensity pain sensation. ASIC4, also designated ACCN4 and BNAC4, is abundant in pituitary gland and is also present in the inner ear. |
| Application Dilution | |
| IHC-P | 1:200-400 |
Frequently asked questions
Which applications is ACCN1 Polyclonal Antibody, HRP Conjugated (bs-4915R-HRP) validated for, and at what dilution?
bs-4915R-HRP is validated for IHC-P (1:200-400). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does ACCN1 Polyclonal Antibody, HRP Conjugated (bs-4915R-HRP) react with?
Tested reactivity: Human, Mouse, Rat.
How should bs-4915R-HRP be stored?
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise ACCN1 Polyclonal Antibody, HRP Conjugated (bs-4915R-HRP)?
KLH conjugated synthetic peptide derived from human CD8B