RUNX2 | CBFA1 Recombinant Antibody, PE-Cy5.5 Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bsm-52672r-pe-cy55-100ul |
| Product Name | RUNX2 | CBFA1 Recombinant Antibody, PE-Cy5.5 Conjugated |
| Applications |
WB
FLOW-CYT
|
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | PE-Cy5.5 |
| Host | Rabbit |
| Source | A synthesized peptide derived from human RUNX2 |
| Immunogen Range | 300-450/521 |
| Clonality | Recombinant |
| Isotype | IgG |
| Concentration | 1mg/ml |
| Purification | purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 860 |
| Swiss Prot | Q13950 |
| Subcellular location | Nucleus |
| Synonyms | AML3; CBF-alpha-1; CBFA1; CCD; CCD1; CLCD; OSF-2; OSF2; PEA2aA; PEBP2aA; Cbf; Cbfa-1; LS3; Pebp2a1; Pebpa2a; RUNX2_HUMAN; RUNX2; Acute myeloid leukemia 3 protein; Core-binding factor subunit alpha-1 (CBF-alpha-1); Oncogene AML-3; Osteoblast-specific transcription factor 2 (OSF-2); Polyomavirus enhancer-binding protein 2 alpha A subunit (PEA2-alpha A | PEBP2-alpha A); SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; PEBP2A; RUNX2_HORSE; RUNX2_MOUSE; RUNX2_RAT; RUNX family transcription factor 2; runt-related transcription factor 2; runt related transcription factor 2 |
| Background | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. |
| Application Dilution | |
| WB | 1:500-2000 |
| Flow-Cyt | 1:100-200 |