phospho-MLKL (Ser345) Recombinant Antibody, Biotin Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bsm-54104r-biotin |
| Product Name | phospho-MLKL (Ser345) Recombinant Antibody, Biotin Conjugated |
| Applications |
WB
IP
|
| Reactivity | Mouse |
| Specifications | |
| Conjugation | Biotin |
| Host | Rabbit |
| Source | Synthetic phospho-peptide corresponding to residues surrounding Ser345 of human MLKL |
| Modification Site | Ser345 |
| Clonality | Recombinant |
| Isotype | IgG |
| Concentration | Lot dependent |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C for 12 months. |
| Target | |
| Gene ID | 74568 |
| Swiss Prot | Q9D2Y4 |
| Synonyms | Phospho-MLKL (S345); pMLKL Ser345; Mixed lineage kinase domain-like protein, Mlkl |
| Background | Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. |
| Application Dilution | |
| WB | 1:300-5000 |
| IP | 1-2ug |