mouse CD45RB/PE
Applications
Reactivity
| Overview | |
| Catalog # | bsm-30160a-pe-100t |
| Product Name | mouse CD45RB/PE |
| Applications |
FCM
|
| Reactivity | Mouse |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rat |
| Clonality | Monoclonal |
| Clone # | 8C7 |
| Isotype | IgG2a/Kappa |
| Concentration | n/a |
| Purification | Affinity purified by Protein G |
| Storage Buffer | 0.01M PBS, 0.5%BSA, 0.02% Proclin300 |
| Storage Condition | Store at 2-8°C |
| Target | |
| Gene ID | 19264.0 |
| Swiss Prot | P06800 |
| Background | CD45RB is an isoform of CD45 with exon 5 splicing (encodes B determinant). It is a 220 kD glycoprotein expressed on peripheral B cells, naïve T cells, thymocytes, weakly on macrophages, and dendritic cells. It plays a critical role in TCR and BCR signaling. As T cells become activated and progress from naïve to memory cells, CD45RB expression is downregulated. Additionally, functionally distinct CD4+ T cell subsets, which secrete differing cytokine profiles, can be separated by CD45RB intensity. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4 and Thy-1. |
| Application Dilution | |
| FCM | 10ul/10^6 cells in 100ul |