NIBR189

Overview
Catalog #	bs-6596c-10mg
Product Name	NIBR189
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 429.31 Formula: C21 H21 Br N2 O3 CAS Number: 1599432-08-2 InChi Key: OFHXXBRBGWUOHR-NYYWCZLTSA-N InChi: InChI=1S/C21H21BrN2O3/c1-27-19-9-5-17(6-10-19)21(26)24-14-12-23(13-15-24)20(25)11-4-16-2-7-18(22)8-3-16/h2-11H,12-15H2,1H3/b11-4+ Smiles: COC1C=CC(=CC=1)C(=O)N1CCN(CC1)C(=O)/C=C/C1C=CC(Br)=CC=1 Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power Shelf Life: 1.0 years
Description	NIBR189 is a potent and selective antagonist of the G protein-coupled receptor identified as EBI2 (GPR183) (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors, respectively). This compound exhibits selectivity for EBI2 over other receptors, enzymes and transporters. In addition, NIBR189 blocks oxysterol-induced migration of U937 monocyte cells.