NSC319726, Mutant p53 Activator

Overview
Catalog #	bs-66047c-10mg
Product Name	NSC319726, Mutant p53 Activator
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 234.32 Formula: C11 H14 N4 S CAS Number: 71555-25-4 InChi Key: XDHBUMNIQRLHGO-UKTHLTGXSA-N InChi: InChI=1S/C11H14N4S/c1-9(10-5-2-3-6-12-10)13-14-11(16)15-7-4-8-15/h2-3,5-6H,4,7-8H2,1H3,(H,14,16)/b13-9+ Smiles: C/C(=N\NC(=S)N1CCC1)/C1C=CC=CN=1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	NSC319726 is a potent and selective activator of mutant p53R175 (EC50 ~8 nM in mutant p53 cell lines but with >100-fold selectivity in wild type cells). It has potent growth inhibitory activity in mutant p53 cells, particularly for the p53R175 mutant. Mechanistic studies revealed that NSC319726 restores WT structure and function to the p53R175 mutant. It kills p53R175H knock-in mice with extensive apoptosis and inhibits xenograft tumor growth in a 175-allele-specific mutant p53-dependent manner. This activity depends upon the zinc ion chelating properties of the compound as well as redox changes. NSC319726 is an attractive lead compound for anti-cancer drug development.