Itaconic acid [Itaconate]

Overview
Catalog #	bs-75203c-1g
Product Name	Itaconic acid [Itaconate]
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 97-65-4 Molecular formula: C5H6O4 Molecular weight: 130.1 Purity: >99% Appearance: White powder. Solubility: Soluble in water, ethanol or methanol. InChiKey: GDMMRLCQKPSXQG-USNJAYOWSA-N SMILES: OC(=O)CC(=C)C(O)=O
Description	Mammalian antibacterial metabolite. Inhibitor of isocitrate lyase, the key enzyme of the glyoxylate cycle, essential for bacterial growth [1, 4]. Antimicrobial. Antibacterial [1, 3, 4]. Inhibits the growth of bacteria expressing isocitrate lyase [1, 3, 4]. Phosphofructokinase (PFKII) inhibitor. Suppresses glycolysis by decreasing the level of fructose 2,6-bisphosphate, resulting in decreased visceral fat [2]. Might be involved in the regulation of metabolism [2]. One of the most highly induced metabolites in activated macrophages. Exerts anti-inflammatory effects in vitro and in vivo. Regulates succinate levels by inhibiting succinate dehydrogenase (SDH). Regulates mitochondrial respiration and cytokine production. Might induce inflammasome activation and consequently IL-1beta secretion by generating ROS.