Berberine chloride

Overview
Catalog #	bs-75940c-10g
Product Name	Berberine chloride
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 633-65-8 Molecular formula: C20H17NO4 . HCl Molecular weight: 335.3 . 36.5 Purity: >98% (TLC) Appearance: Yellow to orange powder. Solubility: Soluble in DMSO or methanol. Slightly soluble in ethanol or water. InChiKey: VKJGBAJNNALVAV-UHFFFAOYSA-M SMILES: [Cl-].COC1=C(OC)C2=C[N+]3=C(C=C2C=C1)C1=CC2=C(OCO2)C=C1CC3
Description	Natural fluorescent dye, used in histology for staining heparin in mast cells. An isoquinoline alkaloid, which shows antibacterial, antifungal, anti-inflammatory, anti-oxidant, antidiabetic, antiviral and anticancer activity. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. Broad spectrum enzyme inhibitor, affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. Increases adiponectin expression, upregulates LDLR and insulin receptor. Anti-hyperglycemic, by inhibition of aldose reductase, inducing glycolysis, preventing insulin resistance through increasing insulin receptor expression and acting like incretins. Activates AMPK and ERK. Potent, uncompetitive, reversible IDO1 inhibitor with IC50 values of 7 µM (cell-based assay) and 9.3 µM (enzymatic assay), and Ki value 8µM. Inhibits BAFF production in H. pylori-induced chronic gastritis.