D-Biotin p-nitrophenyl ester

Overview
Catalog #	bs-75966c-100mg
Product Name	D-Biotin p-nitrophenyl ester
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 33755-53-2 Molecular formula: C16H19N3O5S Molecular weight: 365.4 Purity: >98% (HPLC) Appearance: White to yellow powder. Solubility: Soluble in methanol (25mg/ml). InChiKey: YUDNXDTXQPYKCA-YDHLFZDLSA-N SMILES: O=C(OC1=CC=C([N+]([O-])=O)C=C1)CCCC[C@@H]2SC[C@@]3([H])[C@]2([H])NC(N3)=O
Description	(+)-Biotin 4-nitrophenyl ester (Biotin-ONp) is a pre-activated biotin derivative, that is used as a biotinylation reagent in the modification of peptides, amino acids and proteins. Biotin-ONp is an effective and efficient tool for the introduction of biotin during solid phase synthesis, offering greater reactivity and higher solubility than Biotin-OSu. It may also be used to prepare biotinylated quinazoline derivatives. Recently, Biotin-ONp has been described as an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.