Combretastatin A4

Overview
Catalog #	bs-76096c-10mg
Product Name	Combretastatin A4
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 117048-59-6 Molecular formula: C18H20O5 Molecular weight: 316.35 Purity: >98% (HPLC) Appearance: Off-white powder. Solubility: Soluble in DMSO (10mg/ml), ethanol (5mg/ml) or DMF (10mg/ml). Insoluble in water. InChiKey: HVXBOLULGPECHP-WAYWQWQTSA-N SMILES: OC1=CC(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC SMILES: COC1=CC(\C=C/C2=CC(O)=C(OC)C=C2)=CC(OC)=C1OC
Description	Combretastatin A4 is a natural stilbenoid phenol originally isolated from an African shrub, Combretum caffrum. It is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. CA4 was shown to impede tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma) and MCF-7 (breast cancer). It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A-4 is the active component of combretastatin A-4 phosphate, a prodrug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis. Combretastatin A-4 is therefore a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis.