Demethoxycurcumin

Overview
Catalog #	bs-76250c-5mg
Product Name	Demethoxycurcumin
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 22608-11-3 Molecular formula: C20H18O5 Molecular weight: 338.35 Purity: >98% (HPLC) Appearance: Yellow to orange powder. Solubility: Soluble in DMSO (10mg/ml) or DMF (10mg/ml). InChiKey: HJTVQHVGMGKONQ-LUZURFALSA-N SMILES: OC1=CC=C(/C=C/C(CC(/C=C/C2=CC=C(O)C(OC)=C2)=O)=O)C=C1
Description	Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin with anti-inflammatory and anti-cancer properties. DMC suppresses cell proliferation, migration and invasion in cancer cells. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/beta-catenin pathway, and inhibits lipopolysaccharide induction of iNOS by blocking NF-kappa activation. It also has been shown to inhibit energy metabolic and oncogenic signaling pathways through AMPK activation. In addition it is a potent inhibitor of P-Type ATPases. Shown to have neuroprotective properties. It also has anti-plasmodial activity.