Entecavir monohydrate

Overview
Catalog #	bs-76277c-50mg
Product Name	Entecavir monohydrate
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at RT.
Target
Product Information	CAS Number: 209216-23-9 Molecular formula: C12H15N5O3 . H2O Molecular weight: 295.29 Purity: >98% (HPLC) Appearance: White to off-white powder. Solubility: Solube in DMSO (10mg/ml), DMF (10mg/ml) or methanol. Sparingly soluble in water. InChiKey: YXPVEXCTPGULBZ-WQYNNSOESA-N SMILES: O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)C3=C)C=N2)NC(N)=N1.O SMILES: O.[H][C@]1(O)CC([H])(N2C=NC3=C2NC(=N)N=C3O)C(=C)[C@]1([H])CO
Description	Entecavir is an oral antiviral drug used in the treatment of hepatitis B (HBV) infection. It is marketed under the trade name Baraclude (BMS). Entecavir is a potent deoxyguanosine nucleoside analog with antiviral activity selective for hepadnaviruses. In vitro, the active intracellular form of entecavir, entecavir triphosphate, demonstrates a higher binding affinity for HBV DNA polymerase than the natural guanosine triphosphate substrate and effectively inhibits HBV DNA replication at 3 stages in the replication pathway: priming, reverse transcription and DNA-dependent DNA synthesis. Can be also used as a reference compound.