Fluticasone propionate

Overview
Catalog #	bs-76342c-5mg
Product Name	Fluticasone propionate
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at RT.
Target
Product Information	CAS Number: 80474-14-2 Molecular formula: C25H31F3O5S Molecular weight: 500.57 Purity: >97% (NMR) Appearance: White powder. Solubility: Soluble in DMSO (20mg/ml) or DMF (20mg/ml). InChiKey: WMWTYOKRWGGJOA-CENSZEJFSA-N SMILES: O[C@H]1C[C@@]2(C)[C@](C[C@@H](C)[C@]2(OC(CC)=O)C(SCF)=O)([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@]31F)=O SMILES: [H][C@@]12C[C@@H](C)[C@](OC(=O)CC)(C(=O)SCF)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
Description	Fluticasone propionate is a synthetic corticosteroid. It is a high affinity, selective glucocorticoid receptor agonist (Kd = 0.5nM). It is used as an anti-inflammatory agent for asthma. It has low systemic bioavailability and has been investigated for effectiveness as an inhaled or intranasal corticosteroid to reduce airflow obstruction related to asthma, allergic rhinitis and other airway diseases. It potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis in vitro. It also potentiates KV1 channels (EC50 = 37nM).