Flibanserin

Overview
Catalog #	bs-76344c-5mg
Product Name	Flibanserin
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 167933-07-5 Molecular formula: C20H21F3N4O Molecular weight: 390.4 Purity: >98% (HPLC) Appearance: White to beige powder. Solubility: Soluble in DMSO (20mg/ml), DMF (20mg/ml) or ethanol (10mg/ml) InChiKey: PPRRDFIXUUSXRA-UHFFFAOYSA-N SMILES: O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3 SMILES: FC(F)(F)C1=CC=CC(=C1)N1CCN(CCN2C(=O)NC3=CC=CC=C23)CC1
Description	Flibanserin is a full agonist of the serotonin 5-HT1A receptor and an antagonist of 5-HT2A (Ki=1nm and 49nM, respectively). It also binds to dopamine D4 receptors with Ki values ranging from 4-24nM, but demonstrates no affinity for the other 5-HT subtypes or other neurotransmitter receptors. Multifunctional serotonergic ligands like flibanserin that can enhance downstream release of dopamine and norepinephrine while concomitantly reducing serotonin release in the brain circuits that mediate symptoms of reduced sexual interest and desire, are being studied clinically for therapeutic potential to improve sexual functioning. Flibanserin was investigated as a novel, non-hormonal treatment for pre-menopausal women with Hypoactive Sexual Desire Disorder (HSDD). Flibanserin was also found to reduce L-DOPA-induced dyskinesia in a model of Parkinson‘s Disease.