GSH-OEt

Overview
Catalog #	bs-76348c-100mg
Product Name	GSH-OEt
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 92614-59-0 Molecular formula: C12H21N3O6S Molecular weight: 335.38 Purity: >90% (HPLC) Appearance: Solid. Solubility: Soluble in DMSO (20mg/ml) or water (>100mg/ml). InChiKey: JKRODHBGNBKZLE-YUMQZZPRSA-N SMILES: CCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O
Description	GSH-OEt is cellpermeable and has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. GSH-OEt is a protective agent against cellular damage, such as cataracts and mitochondrial degeneration. It undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Glutathione monoethyl ester may be used to supplement cellular pools of GSH in vitro and in vivo and can prevent ROS formation, neutralize toxic products and block apoptosis pathway. The effect of glutathione (GSH) and glutathione ethyl ester (GSH-OEt) supplementation on GSH homeostasis and exercise-induced oxidative stress was also examined. Glutathione ethyl ester protects against cisplatin-induced ototoxicity in the rat.