Glycyrrhizic acid ammonium salt

Overview
Catalog #	bs-76367c-25g
Product Name	Glycyrrhizic acid ammonium salt
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 53956-04-0 Molecular formula: C42H62O16 . NH3 Molecular weight: 839.96 Purity: >98% (Titr.) Appearance: White powder. Solubility: Soluble in DMSO (10mg/ml). Slightly soluble in water (1mg/ml). InChiKey: ILRKKHJEINIICQ-IERXZFCASA-N SMILES: O=C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](C(O)=O)O[C@@H]2O[C@H]3C(C)(C)[C@@](CC[C@]([C@@](CC[C@]4(C)[C@@]5([H])C[C@@](C)(C(O)=O)CC4)(C)C5=C6)(C)[C@]7([H])C6=O)([H])[C@]7(C)CC3)O1.N SMILES: [NH4+].CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O)C(O)=O
Description	Glycyrrhizic acid is a natural triterpenoid saponin. It is an agonist of the human sweet taste receptor and is used as a flavorant. Glycyrrhizic acid has diverse biological activities, including antioxidant, anti-inflammatory, antidiabetic, anticancer, antimicrobial, hepatoprotective, neuroprotective and antiviral actions. Glycyrrhizic acid has been shown to be a 11-beta-hydroxysteroid dehydrogenase inhibitor, a functional inhibitor of HMGB1 and a highly selective and competitive inhibitor of kynurenine aminotransferase 2 (KAT2). It can enhance GLP-1 secretion through TGR5 activation and has an anti-inflammatory effect by attenuating the generation of excessive NO, PGE(2), and ROS and by suppressing the expression of pro-inflammatory genes through the inhibition of NF-kappa and PI3K activity. It has anti-angiogenic and apoptosis inducing properties. In addition, due to its amphiphilic nature glycyrrhizic acid is able to form self-associates in aqueous and non-aqueous media, as well as water soluble complexes with a wide range of lipophilic drugs. It has been identified as promising carrier material for anticancer therapy, due to its anti-cancer-related pharmacological activities, such as broad-spectrum anti-cancer ability, resistance to the tissue toxicity caused by chemotherapy and radiation, drug absorption enhancing effects and anti-multidrug resistance (MDR) mechanisms.