Hydroxystilbamidine bis(methanesulfonate)

Overview
Catalog #	bs-76409c-10mg
Product Name	Hydroxystilbamidine bis(methanesulfonate)
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 223769-64-0 Molecular formula: C16H16N4O . 2CH4O3S Molecular weight: 280.3 . 192.2 Purity: >95% (HPLC) Appearance: Yellow solid. Solubility: Soluble in water or DMSO (20mg/ml). InChiKey: YGNSQKCULHSJDC-HFPMQDOPSA-N SMILES: OC1=C(/C=C/C2=CC=C(C([NH3+])=N)C=C2)C=CC(C([NH3+])=N)=C1.CS(=O)([O-])=O.CS(=O)([O-])=O SMILES: CS(O)(=O)=O.CS(O)(=O)=O.NC(=N)C1=CC=C(C=CC2=CC=C(C=C2O)C(N)=N)C=C1
Description	Hydroxystilbamidine (also called Fluoro Gold) is a cationic dye used for staining DNA and RNA. It exhibits distinctively different fluorescence emission profiles when bound to DNA compared to RNA. It is also frequently used as a retrograde neuronal tracer. The fluorescent tracer provides intense retrograde labeling that is extremely sensitive and reliable, does not diffuse out of retrograde-labeled neurons, and can be pressure-injected or introduced by iontophoresis into cells. Hydroxystilbamidine is compatible with most frequently used neuroanatomical techniques such as immunofluorescence, immunocytochemistry, autoradiography, and horseradish peroxidase-based histochemistry, paraffin embedding. Gold color is emitted when tissue is processed with a neutral pH buffer while blue/bright white is emitted when an acidic pH buffer is used. Spectral data: lambdaex=361nm and lambdaem=536nm. In addition, hydroxystilbamidine is an amidine antibiotic with antibacterial antifungal, antitrypanosomal, antimalarial and carcinostatic activities. Binds to DNA and RNA in a non-intercalating manner, and is a powerful inhibitor of ribonucleases. Binds also to lysosomes.