Icariin

Overview
Catalog #	bs-76470c-100mg
Product Name	Icariin
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 489-32-7 Molecular formula: C33H40O15 Molecular weight: 676.668 Purity: >97% (HPLC) Appearance: Light yellow fine powder. Solubility: Soluble in DMSO (20mg/ml) or DMF (20mg/ml). InChiKey: TZJALUIVHRYQQB-XLRXWWTNSA-N SMILES: O=C1C2=C(O)C=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C(C/C=C(C)/C)=C2OC(C4=CC=C(OC)C=C4)=C1O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5 SMILES: COC1=CC=C(C=C1)C1=C(O[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)C(=O)C2=C(O)C=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C(CC=C(C)C)=C2O1
Description	Icariin, the active component of the Chinese medicinal plant E. brevicornum. It has been shown to have anti-inflammatory, anticancer, antioxidant, osteoprotective, neuroprotective and cardioprotective activity. It has been shown to enhance bone formation and bone regeneration. Icariin may be beneficial to Alzheimer's disease by reducing the production of extracellular amyloid plaques and intracellular neurofibrillary tangles and inhibiting phosphodiesterase-5 activity. The anti-cancer activity is related to various mechanisms such as apoptosis and autophagy induction, cell cycle modulation, antiangiogenesis and antimetastasis, modulating multidrug resistance and immunomodulation. Icariin interacts with several pathways, like PDE, TGF-beta, MAPK, PPAR, NOS, IGF, Sirtuin and others. Icariin has been shown to inhibit the NF-kappa activation pathway and NLRP3 inflammasome.