Merocyanin 540

Overview
Catalog #	bs-76508c-100mg
Product Name	Merocyanin 540
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 62796-23-0 Molecular formula: C26H32N3NaO6S2 Molecular weight: 569.67 Purity: >90% (HPLC) Appearance: Deep violet powder. Solubility: Soluble in DMSO, ethanol, methanol or water. InChiKey: OSQUFVVXNRMSHL-LTHRDKTGSA-M SMILES: [Na+].CCCCN1C(=O)C(=C\C=C\C=C2/OC3=CC=CC=C3N2CCCS([O-])(=O)=O)C(=O)N(CCCC)C1=S SMILES: [Na+].CCCCN1C(=O)C(=CC=CC=C2OC3=C(C=CC=C3)N2CCCS([O-])(=O)=O)C(=O)N(CCCC)C1=S
Description	Merocyanine 540 (MC-540) is an anionic, lipophilic sensitive fluorescent probe for membrane potential. It is a sodium salt of sulfonic acid, with a chain of four conjugated methine groups, a substituted benzoxazole ring at one end, and substituted thiobarbituric acid at the other end. MC-540 was originally developed as a photosensitizer for photographic emulsions. However, its main importance today is in biology and medicine. It is widely used as a biological probe in membrane studies (fluorescent probe for studies of membrane systems, optical probe for transmembrane potentials), for characterization of the multidrug resistance phenotype, for photo-induced cytotoxicity as a highly effective drug against human malignant cells (photodynamic purging of neoplastic cells in bone marrow explants - leukemia, treatment of lymphomas and metastatic neuroblastomas) and other diseases (malaria, Herpes simplex, HIV). MC-540 has been shown to be a selective stain for leukemic and immature hemopoietic cells in flow cytometry. Spectral Data: Ex/Em: 560/579nm (see Reference 10 for excitation of different solvents). MC-540 is spectrally similar to Alexa Fluor 546, Cy3 (Cyanine-3), Sulforhodamine B, TAMRA and Sulforhodamine B sulfonyl chloride.