Mildronate dihydrate

Overview
Catalog #	bs-76570c-10mg
Product Name	Mildronate dihydrate
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 86426-17-7 Molecular formula: C6H14N2O2 . 2H2O Molecular weight: 182.22 Purity: >98% (HPLC) Appearance: White to off-white powder. Solubility: Soluble in water (20mg/ml) or ethanol (20mg/ml). InChiKey: PVBQYTCFVWZSJK-UHFFFAOYSA-N SMILES: [O-]C(CCN[N+](C)(C)C)=O
Description	Mildronate is a structural analog of gamma-butyrobetaine (gammaBB), an intermediate in the biosynthesis of carnitine and a modulator of energy metabolism. It blocks carnitine synthesis by inhibiting gammaBB hydroxylase (BBOX) and, less potently, carnitine acetyltransferase (CrAT). Through these actions, mildronate reduces the levels of free carnitine and long chain acyl carnitine. This leads to suppressed fatty acid metabolism and mitochondrial uncoupling during oxidative conditions, resulting in cardioprotective, antidiabetic and neuroprotective effects. Mildronate also improves cognition and reduces amyloid-beta pathology in a mouse model of Alzheimer’s disease.