Physil chloride

Overview
Catalog #	bs-76672c-50mg
Product Name	Physil chloride
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 114341-14-9 Molecular formula: C14H10ClNO3S Molecular weight: 307.75 Purity: >98% (HPLC) Appearance: Solid. Solubility: Soluble in acetone. InChiKey: PKWBLDDSBFCSPX-UHFFFAOYSA-N SMILES: ClS(=O)(=O)C1=CC=C(C=C1)N1CC2=CC=CC=C2C1=O SMILES: ClS(=O)(=O)C1=CC=C(C=C1)N1CC2=CC=CC=C2C1=O
Description	It is known that phenol and p-cresol are promoters of skin tumors and also urinary excretion of phenol and p-cresol is increased by exposure to benzene, which has hemopoietic toxicity, and toluene, respectively. Therefore, the determination of phenol and p-cresol is important in clinical chemistry and toxicology. Because phenol and p-cresol are present in urine as sulfate or glucuronide conjugates, they are hydrolyzed enzymatically or with acid, followed by distillation or extraction with organic solvent prior to measurement by GC or HPLC. However, these GC and HPLC methods require relatively large sample volumes (more than 1 ml) because of their insufficient sensitivities for measuring small amounts of phenol and p-cresol. The application of fluorescent labeling techniques to HPLC result in a sensitive and selective method. Phthalimidylbenzenesulfonyl chlorides habe also been successfully used for high sensitivity labelling of amino acids prior to HPLC.